25 A-List Actors Who Were Fired and Replaced During Filming

Anne Hathaway: Knocked Up

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The leading lady was originally cast to play Alison Scott in the 2007 film Knocked Up. But Anne Hathaway wasn’t a fan of the very graphic birth scene that occurs at the end of the film and ended up dropping out. Judd Apatow went on to replace Hathaway with Grey’s Anatomy star Katherine Heigl.